产品货号：
GS4674
中文名称：
重组人NRG1-α
英文名称：
Recombinant Human Neuregulin 1-alpha EGF Domain
产品规格：
10μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 7.4kDa,a single non-glycosylated polypeptide chain containing 65 amino acids.
储存条件：冷冻（-20℃）
概述
Neuregulin 1 belongs to a family of structurally related polypeptide growth factors and is produced in numerous isoforms by alternative splicing,which allows it to perform a wide variety of functions.These isoforms include heregulins(HRGs),glial growth factors(GGFs)and sensory and motor neuron-derived factor(SMDF).They all have the Ig and EGF-like domain,and can bind to ErbB3 and ErbB4 receptor tyrosin kinases.This binding induces ErbB3 and ErbB4 heterodimerization with ErbB2,stimulating intrinsic kinase activity,which leads to tyrosine phosphorylation.NRG1 isoforms have functions of inducing the growth and differentiation of epithelial,neuronal,glial,and other types of cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人NRG1-α，NRG1-α, Human，Recombinant Human Neuregulin 1-alpha EGF Domain
储存条件：冷冻（-20℃）
概述
Neuregulin 1 belongs to a family of structurally related polypeptide growth factors and is produced in numerous isoforms by alternative splicing,which allows it to perform a wide variety of functions.These isoforms include heregulins(HRGs),glial growth factors(GGFs)and sensory and motor neuron-derived factor(SMDF).They all have the Ig and EGF-like domain,and can bind to ErbB3 and ErbB4 receptor tyrosin kinases.This binding induces ErbB3 and ErbB4 heterodimerization with ErbB2,stimulating intrinsic kinase activity,which leads to tyrosine phosphorylation.NRG1 isoforms have functions of inducing the growth and differentiation of epithelial,neuronal,glial,and other types of cells.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 40ng/ml,corresponding to a specific activity of ＞ 2.5×104 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered solution in 20mMPB,pH 6.0,150 mM NaCl. |
| 内毒素 | Less than 0.1 EU/μg of rHuNRG1-α as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCQPGF TGARCTENVP MKVQNQEKAE ELYQK |
相关搜索：重组人NRG1-α，NRG1-α, Human，Recombinant Human Neuregulin 1-alpha EGF Domain